Cancer genetics: gene discovery and translational Research
Date:2018-12-14     View:

Reporter: Jian-Hua Mao, Ph.D.

Contacts: Liu Weiquan



NAME: Jian-Hua Mao, Ph.D.

Geneticist Staff Scientist of Lawrence Berkeley National Laboratory

Life Sciences Division


1. Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, and Balmain A.Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature, 432: 775-9 (2004).

2. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, and Costello JF. Epigenome analyses using BAC microarrays identifies evolutionary conservation of tissue-specific methylation of SHANK3. Nature Genetics, 37: 645-651 (2005).

3. Mao JH, Li J, Jiang T, Li Q, Wu D, Perez-Losada J, DelRosario R, Peterson L, Balmain A, and Cai WW. Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene, 24: 7924-34 (2005).

4. Mao JH, Saunier EF, de Koning JP, McKinnon MM, Higgins MN, Nicklas K, Yang HT, Balmain A, and Akhurst RJ. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci USA, 103: 8125-8130(2006).

5. Mao JH, Wu D, Perez-Losada J, Jiang T, Li Q, Neve RM, Gray JW, Cai WW, and Balmain A. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell, 11:161-73 (2007).

6. Wakabayashi Y, Mao JH, Brown K, Girardi M, and Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice.Nature, 445: 761-765 (2007).

7. Wei G, Ku S, Saito S, Tang AA, Mao JH, Appella E, Balmain A, and Huang EJ. HIPK2 Represses b-catenin-mediated Cyclin D1 Transcription: Role in Epidermal Stem Cells and Tumorigenesis. Proc Natl Acad Sci USA, 104:13040-5 (2007).

8. Mao JH, Kim IJ, Wu D, Climent J,Kang HC, DelRosario R, and Balmain A. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science, 321: 1499-1502 (2008).

9. Mao JH*, DWu, R DelRosario, A Castellanos, A Balmain, and J Perez-Losada. Monoallelic Atm Deficiency does not Increase Tumor Susceptibility to Ionizing Radiation Alone or in a P53 Heterozygous Background. Oncogene, 27:6596-6600 (2008).

10. Quigley DA, To MD, Pérez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, and Balmain A. Genetic architecture of murine skin inflammation and tumor susceptibility. Nature,485: 505-508 (2009).

11. Chun MG, Mao JH, Chiu CW, Balmain A, and Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci USA, 107:17268-73 (2010). PMCID: PMC2951397

12. Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A,Pelorosso FG, DelRosario R,Huang EJ, and Balmain A. Hipk2 cooperates with p53 to suppress g-ray radiation-induced mouse thymic lymphoma. Oncogene, 31: 1176–1180 (2012).


Time: 3 p.m. 27th Dec.2013

Location: Room 2018, Life Science Center

Contacts: Liu Weiquan